yjmC [2017-03-01 14:18:47]

similar to hydroxycarboxylic acid dehydrogenase, may be involved in galacturonate utilization

locus: BSU12320

pI: 5.67

mw: 36.00 kDa

protein length: 337 aa

gene length: 1011 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|ExuR regulon], [SW|SigE regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,303,423 -> 1,304,436

The protein

Protein family

• LDH2/MDH2 oxidoreductase family (according to Swiss-Prot)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Additional information

• The gene is annotated in KEGG as an ortholog of malate dehydrogenase EC 1.1.1.37. but it is marked as “uncharacterized oxidoreductase” (EC 1.1.1.-) in Swiss-Prot. In MetaCyc it is marked as “similar to malate dehydrogenase”. As the paper by Mekjian et al. [Pubmed|9882655] suggests this gene is more likely to be involved in the glucuronate pathway (for which EC 1.1.1.37 is not a member), no literature/experimental evidence supporting the annotation is available. [Pubmed|19935659]

Expression and Regulation: [[this]]

Biological materials

Mutant

• MGNA-A367 (yjmC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/367 NBRP B. subtilis, Japan]

References

• 9579062,9882655,10666464,19935659